What book was penned by Jack London that highlights the struggle against nature?

The correct choice is a celebrated work that thoroughly explores the theme of the struggle against nature through the journey of its main character, Buck, a domesticated dog. In "The Call of the Wild," Buck is forcibly uprooted from his comfortable life in California and thrust into the harsh conditions of the Alaskan Klondike Gold Rush. Through his experiences, Buck learns to adapt to the brutal realities of survival in the wilderness, illustrating the conflict between man (and domestic life) and the untamed forces of nature. London's vivid descriptions and his focus on naturalism emphasize how instinct and adaptability become paramount in overcoming the relentless challenges posed by the environment.

The other options represent different themes and narratives. "The Jungle" focuses on the struggles of immigrant labor in the Chicago meatpacking industry, "The Grapes of Wrath" depicts the plight of displaced farmers during the Great Depression, and "The Great Gatsby" critiques the American Dream through the lens of wealth and social class in the 1920s. Each of these works addresses significant social issues but does not center on the specific struggle against nature as seen in Jack London’s distinguished novel.