What major conflict arose between Native Americans and settlers in the late 19th century?

The major conflict that arose between Native Americans and settlers in the late 19th century is best represented by the Indian Wars. This series of conflicts stemmed from the encroachment of settlers and the U.S. government on Native American lands, particularly following the westward expansion driven by the doctrine of Manifest Destiny. As settlers moved into the Great Plains and the West, they came into direct conflict with Native tribes who were defending their territories and way of life.

The Indian Wars encompassed numerous battles and skirmishes, such as the Sioux Wars, the Nez Perce War, and the Apache Wars, among others, which occurred particularly from the mid-1860s to the late 1890s. This time was marked by the U.S. government's efforts to subdue Native populations and force them onto reservations while also attempting to assimilate them into American culture.

Other conflicts mentioned, such as the War of 1812 and the Civil War, are earlier historical events that do not specifically address the interactions and conflicts resulting from westward expansion in the late 19th century, while the Spanish-American War (1898) focused on overseas territories rather than Native American issues within the continental United States. Thus, the Indian Wars are the